If you have high blood pressure, what medications can you take with grapefruit juice? If your healthcare provider recommends a CCB, amlodipine (Norvasc) may be a good choice. But these interactions may not be as serious as the interaction with nicardipine or felodipine. Other CCBs, like verapamil and nifedipine (Procardia) may also be affected. When taken with grapefruit, CCBs could cause your blood pressure to drop too low.ĬCBs that are most likely to interact with grapefruit include nicardipine, felodipine, and nimodipine (Nymalize). These medications are commonly used to treat high blood pressure. Grapefruit products can increase levels of certain heart medications called calcium channel blockers (CCBs). They may recommend a statin that doesn't interact with it or offer other management tips. Talk to your healthcare provider if you take a statin and love grapefruit products. And still, some believe there’s no need to avoid moderate intake of grapefruit products. Others suggest managing this interaction by lowering the statin dose or avoiding large amounts of grapefruit juice. Some experts think avoiding grapefruit juice with statins is best. Statins that aren’t known to interact with grapefruit include rosuvastatin (Crestor), pravastatin, fluvastatin (Lescol XL), and pitavastatin (Livalo).īut it’s not clear how risky the interaction between grapefruit and statins is. The statins most affected by grapefruit are atorvastatin (Lipitor), lovastatin, and simvastatin (Zocor). This can lead to more statin side effects, like muscle pain and possible muscle breakdown ( rhabdomyolysis). But grapefruit and grapefruit juice can increase the levels of certain statin medications. Statins are first-choice options for treating high cholesterol. Some of the most commonly prescribed medications in the U.S., like statin cholesterol medications, are among those that interact with grapefruit.īelow, we’ll detail 11 medications that can interact with grapefruit juice and how you might manage these interactions. This means that grapefruit could affect how well your medication works or could increase your risk of side effects. The study authors urge physicians to learn more about drug interactions with grapefruit (Thompson, " Shots," NPR, 11/27 United Press International, 11/27 Brown, " Booster Shots," Los Angeles Times, 11/27).If you’re a grapefruit lover, you may be disappointed to learn that grapefruit and grapefruit juice can interact with many medications. The study notes that grapefruits are not the only fruits to cause problems with medications: Seville oranges, pomelos, and limes also contain the same family of disruptive compounds. Popular drugs that interact negatively with grapefruit include various antibiotics, as well as drugs that treat hypertension, high cholesterol, and cancer. "Taking one tablet with a glass of grapefruit juice is like taking five tablets with water," Bailey says. This can effectively cause a medication overdose. When the enzyme doesn't function normally, medications may not degrade and instead circulate in the blood at higher levels than normal. The chemical culprits in grapefruits are called furanocoumarins, which deactivate an enzyme found in the small intestine and liver that breaks down various toxins and an estimated 50% of all drugs. ![]() ![]() Writing in the Canadian Medical Association Journal, Lawson Health Research Institute's David Bailey-who first discovered that the bitter fruit can interact with drugs more than 20 years ago-and colleagues reported that the number of drugs that can interact harmfully with grapefruit has increased from 17 to 43 in the last four years. A new study identifies as many as 85 common medications that interact with grapefruit, and at least 43 such interactions can have serious side effects-including sudden death, kidney failure, and internal bleeding.
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